Florence Foster Jenkins (Meryl Streep) is a New York City heiress and socialite who founded the Verdi Club to celebrate a passionate love for opera and music. As it is 1944 and the U.S. is in the midst of World War II, Florence is of the opinion that “music matters more than ever.” English Shakespearean actor, St. Clair Bayfield (Hugh Grant), is her husband and manager. Despite being married, Florence and Bayfield live in separate residences. She has an apartment in the city while he resides in a house with his secret mistress, Kathleen Weatherley (Rebecca Ferguson). Florence suffers from a long-term case of syphilis, which she contracted from her first husband. The illness has caused her to have various health problems and she takes medications that have toxic side effects, such as mercury and arsenic. Due to the fear of passing the disease on to Bayfield, her current marriage is chaste, and Bayfield fulfills his sexual urges with Kathleen.